Endocrine Abstracts

Diabetes mellitus (DM) is an important cause of morbidity and mortality on a global scale. The pathophysiology of DM involves insulin resistance, even in insulin-treated type 1 DM, which in turn is related to the amount of glucose transporter GLUT4 (Slc2a4 gene). Estrogen activity can be mediated by two distinct receptors (ESR1 and ESR2) and may involve genomic and non-genomic mechanisms. Estrogen has been described as involved in glycemic homeostasis, but the related...